Multiple Sclerosis

- Treatment of Spasticity in MS.

- Sativex in Multiple Sclerosis pain.

- A Study to Evaluate Rituximab in Adults With Relapsing Remitting Multiple Sclerosis (Phase II and III studies).

- A Study to Evaluate the Safety and Efficacy of Rituximab in Adults With Primary Progressive Multiple Sclerosis.

- BEYOND: Betaferon/Betaseron Efficacy Yielding Outcomes of a New Dose. (2008)

- Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis.

- Immunotherapy With BHT-3009 Alone or Combined With Atorvastatin in Patients With Multiple Sclerosis.

- Study of Subcutaneous Daclizumab in Patients With Active, Relapsing Forms of Multiple Sclerosis.

- FORTE - Clinical Trial Comparing Treatment of Relapsing-Remitting Multiple Sclerosis (RR-MS) With Two Doses of Glatiramer Acetate (GA).

- Atorvastatin (Lipitor) Therapy in Patients With Clinically Isolated Syndrome (CIS) at Risk for Multiple Sclerosis. (2008)

- NICE - A Study to Evaluate the Safety and Effectiveness of Novantrone Therapy Followed by Copaxone Treatment for Multiple Sclerosis.

- ASSERT - Assessment Study of Steroid Effect in Relapsing Multiple Sclerosis Subjects Treated With Glatiramer Acetate (Copaxone).

- Follow-Up Study of the BENEFIT Study (Betaferon®/Betaseron® in Newly Emerging Multiple Sclerosis for Initial Treatment).

- Evaluation of a treatment for ambulation in MS.

- Study to Investigate the Immune Response to Influenza Vaccine in Patients With Multiple Sclerosis on Teriflunomide (TERIVA)

- Safety, Tolerability, Efficacy and Optimal Dose Finding Study of BAF312 in Patients With Relapsing-remitting Multiple Sclerosis

Principal Investigator: Dr. Jack Antel

- Extension phase of a 12-Month Study Comparing the Efficacy and Safety of Two Doses of Fingolimod Versus Interferon β-1a in Patients With Relapsing- Remitting Multiple Sclerosis. Phase 3 (2302)

Principal Investigator: Dr. Dr. Jack Antel

- Extension Study to Evaluate Safety, Tolerability and Effects on Efficacy Parameters of FTY720 in Patients with Relapsing Multiple Sclerosis. Phase 2. (2201)

Principal Investigator: Dr. Jack Antel

- Natalizumab Re-Initiation of Dosing (STRATA)

- Efficacy and Safety of BG00012 in Relapsing-Remitting Multiple Sclerosis (DEFINE).

Principal Investigator: Dr. Amit Bar-Or

- A Safety and Efficacy Study of ELND002 in Patients With Relapsing Forms of Multiple Sclerosis

Principal Investigator: Dr. Paul Giacomini

- Dose Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the Cerebrospinal Fluid (CSF)and Safety in Subjects With Secondary Progressive Multiple Sclerosis (SPMS)

Principal Investigator: Dr. Paul Giacomini

- JC-virus (JCV) Epidemiology in Multiple Sclerosis (MS) (JEMS)

Principal Investigator: Dr. Yves Lapierre

- Active-control Study to Determine the Efficacy and Safety of Daclizumab HYP versus Avonex® in Patients with Relapsing-Remitting Multiple Sclerosis

Principal Investigator:Dr. Yves Lapierre

Stroke

- Study of NTx®-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients (REGENESIS-LED).

- Phase 2 Proof-of-Concept Study of the Safety and Efficacy of Alfimeprase to Rapidly Open Arteries and Restore Brain Function Following a Stroke.

- Clot Lysis: Evaluating Accelerated Resolution on Intraventricular Hemorrhage (CLEAR IVH).

- Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke.

- Recombinant Factor VIIa in Acute Intracerebral Haemorrhage.

- PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes.

- Albumin in Acute Ischemic Stroke Trial (ALIAS).

- Prevention of Stroke in Patients with a history of Stroke or Transient Ischemic Attack (PERFORM).

- REGENESIS: A Phase II Prospective, Randomized, Double-Blind, Placebo Controlled Study of NTx™-265: Human Chorionic Gonadotropin (hCG) and Epoetin Alfa (EPO) in Acute Ischemic Stroke Patients.

- Minimally Invasive Surgery Plus rtPA for Interacerebral Hemorrhage Evacuation (MISTIE)

Principal Investigator: Dr. David Sinclair

Pain

- Trial of Efficacy and Safety of Pregabalin in Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy.

- Efficacy Study Measuring The Impact Of Pregabalin On Peripheral Neuropathic Pain.

- A Study of Sativex® for Pain Relief in Patients with Advanced Malignancy (SPRAY).

Parkinson's

- Donepezil (Aricept®) in Parkinson’s Disease Patients With Dementia.

ALS

- Efficacy, Tolerability and Safety of Talampanel in ALS.

- Long term safety and tolerability study of SR 57746A in Patients with Amyotrophic Lateral Sclerosis (ALS).

- Lithium for the treatment of ALS.

- Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (BIO_ALS-01)

Principal Investigator: Dr. Angela Genge

Brain Tumor

- The PRECISE Trial: Study of IL13-PE38QQR Compared to GLIADEL Wafer in Patients with Recurrent Glioblastoma Multiforme.

- Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma (SAPPHIRE)

Principal Investigator:Dr. Rolando del Maestro

- Study of Multiple Doses and Regimens of XL184 in Subjects with Grade IV Astrocytic Tumors in First or Second Relapse

Principal Investigator: Dr. Evgenia Garoufalis

- Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status (CENTRIC)

Principal Investigator: Dr. Thierry Muanza

Migraine

- A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches.

- Acute Treatment of Multiple Migraines With or Without Aura in Adults.

Epilepsy

- Safety and Tolerability of OXC XR as Adjunctive Therapy in Subjects With Refractory Partial Epilepsy. 804P302.

- Phase 3 Study to Evaluate Efficacy and Safety of Oxcarbazepine Extended-Release in Subjects With Refractory Partial Seizures Due to Epilepsy When Used With up to 3 Other Antiepileptic Drugs. 804P301.

Revised April 22, 2012