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{"id":7771,"date":"2023-01-30T15:53:06","date_gmt":"2023-01-30T20:53:06","guid":{"rendered":"https:\/\/cru.mcgill.ca\/?p=7771"},"modified":"2023-02-22T14:41:57","modified_gmt":"2023-02-22T19:41:57","slug":"nouveau-chapitre-alz","status":"publish","type":"post","link":"https:\/\/cru.mcgill.ca\/fr\/nouveau-chapitre-alz\/","title":{"rendered":"Nouveau chapitre dans la recherche sur la maladie d’Alzheimer"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.9.10″ _module_preset=”default” background_enable_color=”off” width=”100%” max_width=”100%” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”||||false|false” custom_padding=”100px||||false|false” global_module=”4368″ saved_tabs=”all” width__hover_enabled=”on|desktop”][et_pb_fullwidth_menu menu_id=”25″ menu_style=”centered” submenu_direction=”downwards” fullwidth_menu=”off” dropdown_menu_bg_color=”#353535″ dropdown_menu_line_color=”rgba(0,0,0,0)” dropdown_menu_text_color=”#ffffff” mobile_menu_bg_color=”rgba(0,0,0,0.67)” _builder_version=”4.8.1″ menu_font=”Fabriga||||||||” menu_text_color=”#ffffff” menu_font_size=”15px” menu_line_height=”0em” background_color=”#1e1e1e” background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” width=”100%” height=”52px” custom_margin=”-12px||0px||false|false” custom_margin_last_edited=”off|desktop” custom_padding=”0px||3px||false|false”][\/et_pb_fullwidth_menu][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” admin_label=”Section” _builder_version=”4.9.10″ module_alignment=”center” custom_margin=”-80px||||false|false” custom_padding=”0px|0px|0|0px|false|false” box_shadow_style=”preset1″ box_shadow_vertical=”6px” box_shadow_blur=”37px” box_shadow_spread=”8px” global_module=”3032″ saved_tabs=”all”][et_pb_fullwidth_menu menu_id=”25″ menu_style=”centered” fullwidth_menu=”off” dropdown_menu_bg_color=”#353535″ dropdown_menu_line_color=”rgba(0,0,0,0)” dropdown_menu_text_color=”#ffffff” mobile_menu_bg_color=”rgba(0,0,0,0.67)” _builder_version=”4.9.10″ menu_font=”Fabriga||||||||” menu_text_color=”#ffffff” menu_font_size=”15px” menu_line_height=”0em” background_color=”#1e1e1e” background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” width=”100%” module_alignment=”left” height=”52px” custom_margin=”-12px||||false|false” custom_margin_last_edited=”off|desktop” custom_padding=”0px||0px||false|false”][\/et_pb_fullwidth_menu][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.9.10″ custom_margin=”|||0px|false|false” custom_padding=”0|0px|0|0px|false|false” bottom_divider_height=”0px” border_width_bottom=”1px” border_color_bottom=”#efefef”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.9.10″ width=”100%” max_width=”254%” min_height=”1084px” custom_margin=”|20px||0px|false|false” custom_margin_tablet=”||0px|” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”0px|50px||200px|false|false” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%”][et_pb_column type=”3_5″ _builder_version=”4.3.4″ custom_padding=”||6%|12%|false|false” custom_padding_tablet=”|50px|50px|50px|false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” padding_tablet=”50px|50px|50px|50px” padding_last_edited=”on|tablet” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.10″ custom_margin=”40px||-10px||false|false” custom_padding=”0px||0px|||”]<\/p>\n

Un nouveau chapitre dans la recherche sur la maladie d’Alzheimer<\/strong><\/h1>\n

[\/et_pb_text][et_pb_image src=”https:\/\/cru.mcgill.ca\/wp-content\/uploads\/Alzheimer-pt-hcp-2.jpg” title_text=”Alzheimer pt hcp” align=”center” _builder_version=”4.9.10″ _module_preset=”default” custom_padding=”20px||||false|false”][\/et_pb_image][et_pb_text _builder_version=”4.9.10″ custom_margin=”40px||-10px||false|false” custom_padding=”0px||0px|||”]<\/p>\n

Des recherches cliniques novatrices se tournent vers des traitements compl\u00e9mentaires pour mieux g\u00e9rer la d\u00e9mence<\/em><\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.10″ text_font=”Arial||||||||” custom_margin=”||||false|false” custom_padding=”0px||0px|||” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

20 f\u00e9vrier 2023
<\/em>par Sophie Lorenzo<\/em><\/p>\n

 <\/p>\n

\u00ab Ce que nous voyons maintenant dans la recherche, c’est une nouvelle strat\u00e9gie pour d\u00e9velopper des traitements pour la maladie d’Alzheimer \u00bb, explique le Dr Simon Ducharme, neuropsychiatre et directeur de la division de G\u00e9rontopsychiatrie \u00e0 l’Universit\u00e9 McGill.<\/p>\n

Chez une personne atteinte de la maladie d’Alzheimer, des niveaux anormaux de prot\u00e9ine amylo\u00efde naturelle s’agglutinent pour former des plaques qui s’accumulent entre les neurones et perturbent la fonction cellulaire. Cette ann\u00e9e, une nouvelle th\u00e9rapie (lecanemab) qui utilise des anticorps pour \u00e9liminer l’amylo\u00efde a obtenu une approbation acc\u00e9l\u00e9r\u00e9e aux \u00c9tats-Unis. Le traitement approuv\u00e9 a d\u00e9montr\u00e9 un ralentissement de la progression dans les premiers stades de la maladie.<\/p>\n

\u00ab Maintenant que les traitements pour ralentir la progression commencent \u00e0 \u00eatre approuv\u00e9s, nous cherchons \u00e0 combiner diff\u00e9rents m\u00e9canismes d’action pour mieux g\u00e9rer la maladie. C’est comme en oncologie o\u00f9 l’on combine deux ou trois m\u00e9canismes d’action diff\u00e9rents pour obtenir un effet significatif dans le traitement \u00bb, a observ\u00e9 le Dr Ducharme.<\/p>\n

Un pas essentiel pour atteindre ce but est d\u2019accro\u00eetre notre capacit\u00e9 \u00e0 am\u00e9liorer la qualit\u00e9 de vie des patients confront\u00e9s \u00e0 des troubles neurocognitifs. L’Association Alzheimer du Canada estime qu’il y aura plus de 1,5 million de personnes au Canada vivant avec la d\u00e9mence d’ici 2050.<\/p>\n

\u00a0<\/strong><\/p>\n

Cibler l\u2019amyloid \u00e0 la source<\/strong><\/h3>\n

Le Dr Ducharme est \u00e9galement l’un des chercheurs principaux des essais neurocognitifs \u00e0 l’Unit\u00e9 de recherche clinique du Neuro (Institut neurologique-H\u00f4pital de Montr\u00e9al) qui compte actuellement une demi-douzaine d’\u00e9tudes en cours sur la d\u00e9mence, examinant diff\u00e9rentes approches de traitement des troubles cognitifs l\u00e9gers, ainsi que la maladie d’Alzheimer pr\u00e9coce et mod\u00e9r\u00e9e.<\/p>\n

L’un des essais en cours, ALN-APP-001 teste un nouveau m\u00e9canisme d’action potentiel dans le traitement de la maladie d’Alzheimer en se concentrant sur une approche innovante pour avoir un impact sur la cascade amylo\u00efde. \u00ab La mol\u00e9cule test\u00e9e est con\u00e7u pour bloquer l’ARN messager (transcription g\u00e9nique) du g\u00e8ne de la prot\u00e9ine pr\u00e9curseur de l’amylo\u00efde (APP) qui est responsable de la production de l’amylo\u00efde qui s’accumule anormalement dans le cerveau des personnes atteintes de la maladie d’Alzheimer \u00bb, note le Dr Ducharme. \u00ab Ce qui est innovant ici, c’est l’approche qui consiste \u00e0 intervenir plus t\u00f4t dans la production de la plaque amyloid que les traitements existants ; l’objectif est de bloquer la production de cette prot\u00e9ine \u00e0 la source, plut\u00f4t que d’attendre qu’elle s’accumule et l’\u00e9limine. \u00bb<\/p>\n

Cet essai de phase 1 s’adresse aux personnes atteintes de troubles cognitifs l\u00e9gers et de d\u00e9mence l\u00e9g\u00e8re dus \u00e0 l’apparition pr\u00e9coce de la maladie d’Alzheimer, une variante qui touche les jeunes patients de moins de 65 ans. Selon la Soci\u00e9t\u00e9 Alzheimer du Canada, les patients atteints de la maladie d’Alzheimer pr\u00e9coce repr\u00e9sentent un petit sous-groupe de toutes les personnes atteintes de d\u00e9mence au Canada, mais font face \u00e0 d\u00e9fis accrus car ils sont g\u00e9n\u00e9ralement encore sur le march\u00e9 du travail et \u00e9l\u00e8vent des familles. Apr\u00e8s la deuxi\u00e8me dose, tous les participants \u00e0 l’essai recevront le traitement exp\u00e9rimental.<\/p>\n

 <\/p>\n

Des performances stimulantes<\/strong><\/h3>\n

D’autres \u00e9tudes en cours de d\u00e9veloppement chercheront \u00e0 am\u00e9liorer les performances cognitives. “La recherche sur la maladie d’Alzheimer au cours de la derni\u00e8re d\u00e9cennie a consist\u00e9 \u00e0 ralentir la progression comme objectif ultime. Les \u00e9tudes \u00e0 venir s’inscrivent dans la lign\u00e9e des recherches ant\u00e9rieures qui ont men\u00e9 au d\u00e9veloppement de th\u00e9rapies comme le don\u00e9p\u00e9zil (Aricept) qui visent \u00e0 am\u00e9liorer les performances et les fonctions cognitives \u00bb, explique le Dr Ducharme.<\/p>\n

\u00ab Il est encourageant que nous ayons de nouveaux traitements approuv\u00e9s \u00e0 offrir aux patients, mais nous ne sommes pas satisfaits de l’ampleur de l’effet. De nouvelles \u00e9tudes ciblant diff\u00e9rents m\u00e9canismes d’action laissent esp\u00e9rer qu’on pourra \u00e9ventuellement les combiner comme des blocs de construction avec des traitements existants pour avoir un effet beaucoup plus significatif \u00bb, conclut le Dr Ducharme.<\/p>\n

Pour plus d’informations sur les essais en cours \u00e0 l\u2019URC, contactez neurocog-cru.neuro@mcgill.ca ou visitez cru.mcgill.ca\/fr\/ad_fr\/.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.3.4″ custom_padding=”|50px||50px|false|false” custom_padding__hover=”|||”][et_pb_social_media_follow icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”18px” disabled_on=”on|on|on” admin_label=”Social Media Follow” _builder_version=”4.9.10″ _module_preset=”default” custom_button=”on” button_bg_color=”RGBA(0,0,0,0)” text_orientation=”left” custom_margin=”40px||40px||false|false” custom_padding=”0px||||false|false” sticky_position=”top” sticky_offset_top=”20px” border_color_all=”#4B0084″ disabled=”on” global_module=”4991″ saved_tabs=”all”][et_pb_social_media_follow_network social_network=”instagram” url=”https:\/\/www.instagram.com\/neurocru” _builder_version=”4.9.10″ _module_preset=”default” follow_button=”off” url_new_window=”on”]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.9.10″ text_font_size=”17px” text_line_height=”1.2em” background_color=”#4B0084″ width=”300%” max_width=”150px” custom_margin=”110px|80px||5px|false|false” custom_padding=”10px|3px|10px|13px|false|false” link_option_url=”https:\/\/cru.mcgill.ca\/fr\/essais\/” border_radii=”on|12px|12px|12px|12px”]<\/p>\n

Pour tous les essais en cours,\u00a0 visitez cru.mcgill.ca\/fr\/essais<\/span><\/a><\/span><\/strong>.<\/a><\/span><\/p>\n

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