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Neuro-oncologie (tumeur cérébrale)

Pour plus d’informations sur les essais cliniques sur la tumeur cérébrale, veuillez contacter Lisa Nezvitsky, lisa.nezvitsky@mcgill.ca.

Études actuelles en recrutement

Étude ouverte randomisée de Phase 2/3 portant sur Toca 511, un vecteur rétroviral réplicatif, utilisé en association avec Toca FC, comparativement au traitement standard chez les sujets qui subissent une résection planifiée d’un glioblastome ou d’un astrocytome anaplasique récurrent.

From clinicaltrials.gov:
This is a multicenter, randomized, open-label phase 2/3 study of Toca 511 and Toca FC versus standard of care that comprises Investigator’s choice of single agent chemotherapy (lomustine or temozolomide) or bevacizumab administered to subjects undergoing resection for first or second recurrence (including this recurrence) of GBM or AA. Subjects meeting all of the inclusion and none of the exclusion criteria will be randomized prior to surgery in a 1:1 ratio to receive either Toca 511 and Toca FC (Experimental arm, Arm T) or control treatment with one option of standard of care (Arm SOC). Stratification will be done by IDH1 mutation status. A second stratification factor is based on the patient’s Karnofsky Performance Score (KPS) (70-80 vs 90-100). Further, to account for potential differences in treatment choices for the control arm in regions, the trial will be stratified by geographical region during the randomization process.

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Étude ouverte de phase 3 et à répartition aléatoire visant à évaluer l’efficacité potentielle et l’innocuité de l’éflornithine associée à la lomustine comparativement à la lomustine en monothérapie chez des patients atteints d’un astrocytome anaplasique qui progresse ou récidive après une radiothérapie et une chimiothérapie adjuvante par témozolomide

From clinicaltrials.gov:
The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy.

This study will consist of 4 study periods of up to 50 months in total, consisting of:

Screening Period – A maximum screening duration of 4 weeks.

Treatment Period – Treatment Arm A up to 24 months; Treatment Arm B up to 12 months.

End of Treatment Visit – A minimum of 4 weeks post last treatment for both arms.

Follow-Up Period – Up to 24 months.

A total of approximately 280 patients will be randomized in a 1:1 ratio to receive either eflornithine + lomustine or lomustine alone.

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Étude de phase III multicentrique et randomisée de radiothérapie peropératoire dans le cas du glioblastome multiforme nouvellement diagnostiqué

From clinicaltrials.gov:
INTRAGO II resembles a multicentric, prospective, randomized, 2-arm, open-label clinical phase III trial which tests if the median progression-free survival (PFS) of patients with newly diagnosed glioblastoma multiforme (GBM) can be improved by the addition of intraoperative radiotherapy (IORT) to standard radiochemotherapy.

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A Phase II Trial of Concurrent Sunitinib, Temozolomide and Radiation Therapy followed by Adjuvant Sunitinib and Temozolomide for Newly Diagnosed Glioblastoma Patients with an Unmethylated MGMT Gene Promoter.

Principal Investigator: Bassam Abdulkarim Phone: 514-934-1934, x43594 (MGH) Email: bassam.abdulkarim@mcgill.ca

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Études actives (ne recrutent pas)