Parkinson’s and Movement Disorders
For information on Parkinson’s and Movement Disorders clinical trials, please contact Salma Khalil.
Current Recruiting Studies
This is an open-label, postmarketing, observational study to document health outcomes, in Canadian patients with advanced Parkinson’s disease and long-term treatment with Duodopa (levodopa/carbidopa intestinal gel).
Part 1: To determine the safety and tolerability of GZ/SAR402671 administered orally, as compared to placebo in patients with early-stage Parkinson’s disease (PD) carrying a GBA mutation or other pre-specified variants.
Part 2: To determine the efficacy of GZ/SAR402671 administered orally daily, as compared to placebo in patients with early-stage Parkinson’s disease carrying a GBA mutation or other pre-specified variants.
To evaluate the dose-related safety of BIIB054, to evaluate the pharmacodynamic effects of BIIB054 on the integrity of nigrostriatal dopaminergic nerve terminals, to assess the pharmacokinetic (PK) profile of BIIB054 and to evaluate the immunogenicity of BIIB054.
Active Studies (not recruiting)
The purpose of this study is to assess efficacy, safety, tolerability, and pharmacokinetics of ABBV-8E12 in subjects with progressive supranuclear palsy (PSP).